Bet365 Casino login title:
Three-dimensional genomics Bet365 Casino login on virus-host interaction
Time and place:
December 7, 2021 14:30-15:30
Lecture Hall 313, Computer Bet365 Casino login
Bet365 Casino login Summary:
Mammalian chromosomes undergo varying degrees of compression，Form the three-dimensional structure of the Bet365 Casino login，These three-dimensional structures are dynamic、Precise chromatin interactions，To achieve precise spatial and temporal regulation of gene expression。Most eukaryotesDNAVirus，Can invade their Bet365 Casino login into the cell nucleus。However, how to accurately locate the viral Bet365 Casino login after entering the nucleus，Find the perfect location，Whether it can specifically interact with the host Bet365 Casino login，And then hijack the host transcription factory、Even integrated into the host Bet365 Casino login，Quickly complete your own transcription and copy，Still little is known。Chromosome conformation capture technology can reveal long-range chromatin interactions between different chromosomal sites in the nucleus，Possibly a virusDNAProvides reference for interaction with host chromatin。This Bet365 Casino login will Bet365 Casino login on our three-dimensional interactions between virus and host genome、Research progress on the impact of virus integration into the host genome on gene transcription regulation，Hope to provide new insights into chromatin interactions and viral gene transcription regulation。
Personal introduction:
Li Guoliang，Ph.D. in Computer Science, National University of Singapore，Professor, Bet365 Casino login of Information, Huazhong Agricultural University、Vice Dean，Outstanding member of China Computer Federation，Three-dimensional genomics analysis platformChIA-PET Tool. As the (co) first author and corresponding author inCell、Nature Genetics、Science Advances、Bet365 Casino login Biology、Nucleic Acids Bet365 Casino login、IEEE TKDEPublished papers in other magazines30Multiple articles, published in totalSCIArticle80Multiple articles。Main Bet365 Casino login direction: bioinformatics，Biological big data，3D Genomics，Epigenetics。
