bet365 online sports betting title： Research on key amino acids that affect the binding affinity between ACE2 and novel coronavirus among different bet365 online sports betting
bet365 online sports betting time： 2022year3month2日 Afternoon 15:00
Reporting location： Tencent conference number:870-895-875
bet365 online sports betting Sue the person： Fang Senbiao Doctor
bet365 online sports betting Summary：
Atypical new coronavirus pneumonia has becomeInternational public health emergency, seriously threatening human health and life safety around the world.Not only can the new coronaviruscausing disease in humans，Even other bet365 online sports betting can serve as virus hosts，Cause"animal-animal" and "animal-Cross infection between people，A fatal threat to human health and global ecological balance。
atthisbet365 online sports betting中，Based onNCBIbet365 online sports betting database,Passed"Full sequence"、Methods for sequence alignment of “key peptides”，Selected and sourcedACE2bet365 online sports betting sequence similarity60%And have a close relationship with humans191bet365 online sports betting. Obtained through homology modeling method191of bet365 online sports bettingACE2bet365 online sports betting structure and further acquisition of coronavirus2019-nCov-Spikeand human-specific target receptorACE2bet365 online sports betting complex structure。Overlay by structure，Getting coronavirus2019-nCov-SpikeRegions and different bet365 online sports bettingACE2Direct interface between proteins。Subsequently, using molecular dynamics simulation methods,Calculate the interaction energy and binding mode between each complex system。Discovered by energy comparison analysis44bet365 online sports betting have higher binding energies than those of human origin. passTo many bet365 online sports betting"bet365 online sports betting-Protein" binding interface is statistically analyzed and all bet365 online sports betting are foundACE2On bet365 online sports bettingContains14“key” polar bet365 online sports betting sites, for stableACE2/2019-nCov-SpikeInteraction accounts for the absolute contribution. in,10polar bet365 online sports betting positions are relatively stable, ensuring coronavirus2019-nCov-SpikeProteins and different bet365 online sports bettingACE2. in addition,ACE2Present on bet365 online sports betting4bet365 online sports betting sites (human bet365 online sports betting coding position:Asp30、Lys31、His34andGlu35), possible actor "triggeringThe effect of "trigger"，Amino acid differences can significantly affect different bet365 online sports bettingACE2/2019-nCov-SpikeInterbinding free energy，Plays a crucial decisive role in combining different bet365 online sports betting with coronaviruses。This studyFor studying different bet365 online sports bettingACE2The binding mechanism and pathogenic mechanism between protein and virus，And cross-infection between bet365 online sports betting、Follow-up vaccine and drug development、Maintaining global ecological balance has strong theoretical guiding significance。
