Bet365 title：Development and application of Bet365 characterization algorithm
Bet365 time:March 24, 2022，Thursday，10:00 AM
Tencent Conference:917-801-753
Bet365 Summer:Associate Researcher Chen Hebing Institute of Military Medicine, Bet365 of Military Sciences, Beijing Science and Technology Star
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The Bet365 in human cells is very complex, lengthAbout 2 meters of DNA is entangled in the micron-level nucleus，Transcription is performed in an orderly manner in a highly complex structure、Copy、Repair and other functions，Regulate complex gene expression system。Single cell data display，Bet365 changes dynamically over time，And there may also be heterogeneity in the Bet365 of the same type of cells。Then，How to characterize the changes in Bet365 that can affect gene expression or even cause disease？Around this issue，We start from the basic unit of Bet365—chromatin topologically associated domain，TAD）Get it，Characterize Bet365、Quantitative characterization，And mine TAD-related tumor markers: 1) Constructed the chromatin open density index SDOC to characterize the activity of TAD；2) Based on TAD boundary changes and transcription abnormalities，Constructed the TARGET computational framework to screen oncogenes；3) Changes based on TAD hierarchical structure，Definition of TH score indicator，It was found that changes in TH score of genes are significantly related to the malignant phenotype and poor prognosis of tumors。
Personal introduction:
Chen Hebing，Associate researcher at the Bet365 of Military Medicine, Bet365 of Military Sciences，Beijing Science and Technology Star。Mainly studies the structure and function of chromatin，Use deep learning and other methods to develop and apply three-dimensional genome calculation methods。As the person in charge of the National Natural Youth Project、General projects and various topics such as the Science and Technology Committee of the Military Commission，Be the first or corresponding author (including co-authors) inNature Machine Intelligence、Nucleic Acids Research、PLoS Computational Biology、Briefings in Bioinformatics、20 research papers published in professional journals such as Bioinformatics，Authorized 4 Chinese invention patents。Served as a special guest editor Bet365 "Three-dimensional Genome" special issue Bet365 journal "Quantitative Biology"，Concurrently serves as a member Bet365 Bioinformatics and Artificial Life Professional Committee Bet365 Chinese Artificial Intelligence Society、Member Bet365 Intelligent Health and Bioinformatics Professional Committee Bet365 Chinese Society of Automation。
