Report time：April 24No.19:00-21:00
Reporting location: Information Building, New Campus, Central South Bet365 lotto review535Conference Room
Report 1
Title:A new generation of efficient storage and management model for genome-wide genetic data of hundreds of millions of samples
Report Summary:
Resolving genetic maps of complex disease phenotypes often requires processing genotype data from large-scale samples，for example packageUKBBWhole-genome genotypes of more than 400,000 subjects have been obtained (100TB）。However，Due to the lack of efficient data structures and access algorithms，Storage of large-scale genotype data、Visit、Very difficult to manage and calculate。For this，We propose a new genotype data block structure (GenoType Block，GTB) and corresponding high parallelismIOFrame(Genotype Blocking Compressor，GBC）。GTBis a high-speed addressable、Uniform byte encoding data structure，Can help users store and manage genotype data efficiently。At the same time，GBCThrough optimized parallel compression and decompression process，Increase the speed of data access and management，Realizing fast reading and writing of genotype data。While maintaining a high compression ratio，GBCAccess and manage compressed large-scale genotypes up to speed compared to competing methods1000More than times, performed on an ordinary workstationUKBBCalculated linkage disequilibrium ratio of genotypesPLINK V1.9The algorithm is fast56More than times.GBCProvides a friendly interactive interface and richAPIFunction library，may become an indispensable tool in the future Bet365 lotto review of large-scale genotype data。
About the speaker
Professors introduced by Bet365 lotto review Yat-sen University’s “Hundred Talents Plan”，Director of the Medical Informatics Teaching and Research Office，Excellent scholar of Yixian.2009Received a doctorate from the Bet365 lotto review of Hong Kong in 2008.2013Established at the Faculty of Medicine of the Bet365 lotto review of Hong Kong since the beginning of the yearPrecision medicineBet365 lotto review Team,2016Joined Zhongshan Medical College of Bet365 lotto review Yat-sen University full-time at the end of the year。Precision prevention and control around hereditary epidemics，Based on interdisciplinary strategy，Focus on the development of efficient disease-causing gene mapping theories and original methods，In Genetics、Bioinformatics and other fields have achieved a number of results that are highly recognized by international peers，Last corresponding authorPaper published inAmerican Journal of Human Genetics、Genome Biologyand other authoritative journals, total citations Bet365 lotto review paperMore than seven thousand times，The method has been written into BGI data analysis standards and many other domestic and foreign professional tutorials，Part Bet365 lotto review results are integrated and implemented inKGGIn series software。2021Won the Hong Kong Best Young Scholar Award.
Report 2
Title: Human microbiome Bet365 lotto review driven by high-throughput sequencing
Report Summary:
The Bet365 lotto review object of microbiomics is human symbiotic microorganisms (mainly intestinal flora)，The development of high-throughput sequencing technology and the corresponding evolution of bioinformatics technology have greatly promoted our Bet365 lotto review on human commensal microorganisms。What are symbiotic microorganisms？What are they doing？How they are formed？These questions are important to us as the “host”-It is crucial to understand human health and disease from the perspective of the symbiotic ecosystem of "microorganisms"。Ding Tao’s Bet365 lotto review group applies high-throughput sequencing methods，Developing bioinformatics tools to systematically study microbiome data，Study the biological and medical significance of its indication。The Bet365 lotto review team’s early stage was based onDMMThe model proposes the human microbiome community group pattern (community type) concept，Established a series of corresponding methods to study the dynamics and determinants of human flora。The current Bet365 lotto review focus of the Bet365 lotto review team is the determinants and assembly process of human flora，The latest Bet365 lotto review proposes that the differential input of oral and nasal microorganisms determines the diversity of lung flora based on the neutral model，Revealing the assembly process of lung flora。
About the speaker
Ding Tao，Professor of Zhongshan Medical College, Bet365 lotto review Yat-sen University，Doctoral supervisor。National high-level overseas introduction of young talents (Organization Department of the Central Committee of the CPC)，Outstanding young and middle-aged talents in Bet365 lotto review Yat-sen University’s “Hundred Talents Plan”，Excellent scholar of Yixian.Currently, he is the deputy director of the Microecological Medicine Branch of the Guangdong Association for Precision Medicine Application、Member of the Intestinal Flora Branch of the Chinese Biophysical Society、Director of Guangdong, Hong Kong and Macao Intestinal Microecology Alliance。Internationally renowned journal in the field of microbiomicsMicrobiomeandISMEReviewer。Currently hosting and participating in national natural sciences、Many projects including National Key R&D Plan and Guangdong Provincial Science and Technology Plan Project。So far as the first author or corresponding authorNature、Advanced Science、Microbiome、Microbiology Spectrum、mBioPublished many Bet365 lotto review papers in high-level magazines such as 23144_23159
