bet365 online sports betting app time:April 20247Day (week日）morningStart at 10 o'clock
Reporting location: Computer Building of the school headquarters313
bet365 online sports betting app title: Analysis of dynamic effects of anti-tumor drugs at the single cell level
bet365 online sports betting app summary: Gemcitabine is commonly used in pancreatic ductal adenocarcinoma (PDAC），However, chemotherapy resistance is still a problem in the treatment of PDAC。Understanding cellular heterogeneity and dynamic plasticity is critical to overcoming tumor drug resistance。Single-bet365 online sports betting app technology enables analysis of bet365 online sports betting app status under specific conditions or time points，But how to connect the "snapshots" of tumor cells at each time point into a dynamic picture is still very challenging。The research team used scRNA-seq technology to detect the PDAC heterologous transplant model，To study the complex cellular responses associated with gemcitabine resistance。To reconstruct the dynamic response of tumor cells from perturbed scRNA-seq data，We propose scConGraph scalable two-layer graph model，Can efficiently integrate cross-temporal contextual similarity information to compute vector representations of cells，Then define bet365 online sports betting app subpopulations in the representation space、Align bet365 online sports betting app state fate。Based onscConGraph，We observed that stem bet365 online sports betting app properties and endoplasmic reticulum stress contribute significantly to primary drug resistance。Meanwhile，Before and after gemcitabine treatment，Different patterns of changes according to genetic differences，bet365 online sports betting app subpopulations can be divided into bet365 online sports betting app cycle type I、bet365 online sports betting app cycle type II、Silent type and epithelial-mesenchymal transition (EMT) type。Further analysis found that gemcitabine causes upregulation of GDF15，Especially in the resting subpopulation, the upregulation is more obvious。Experimental confirmation，Inhibiting GDF15 increases the sensitivity of tumor cells to gemcitabine，This suggests that GDF15 is a potential target for gemcitabine-induced chemotherapy resistance。
About the speaker: Gu Jin，Department of Automation, Tsinghua bet365 online sports betting app，Permanently appointed associate professor。The research team focuses on key problems in analyzing the genetic code of life and the regulation laws of complex systems，Develop new information theory and intelligent technology，Promote precision and individualization of diagnosis and treatment of major diseases such as malignant tumors，Already hereNature bet365 online sports betting app Biology、bet365 online sports betting app Stem bet365 online sports betting app、GPB、More than 50 papers published in Bioinformatics and other magazines。Currently Secretary General of the Intelligent Health and Bioinformatics Committee of the Chinese Society of Automation、Standing Member of the Bioinformatics and Artificial Intelligence Professional Committee of the Chinese Artificial Intelligence Society。Host the National Natural Science Foundation of China Outstanding Youth Science Fund、Key projects、National key research and development project and other national scientific research projects。
