Reporter：Limsoon Wongbet365 sports betting app,bet365 sports betting app University of Singapore
Report title:
Single-cell RNA-seq dataset integration without loss of unique rare cell populations
Date and time：2024Year5month8日(Wednesday), PM15:00 – 16:00
Reporting location:Computer Building 313
Report Summary:Typically, batch effect-correction methods for scRNA-seq data search aggressively for overlapping populations of identical cell types across the different batches as anchors relating the cell populations between batches. This has a lamentable consequence that cell populations exclusive to a single batch tend to be wrongly matched and mis-corrected into different cell types. This makes it harder in using scRNA-seq for applications such as detection of pre-malignant cells. In this short talk, I describe MapBatch, which adopts a different approach. The ensemble of autoencoder models in MapBatch, each independently trained on a different single batch to prevent batch effects from being learned and incorporated into the projections, collectively enable biological signals from rare cell populations exclusive to a batch to be easily retained while eliminating batch effects.
About the speaker：bet365 sports betting app Wong Limsoon(bet365 sports betting app Huang Renxiang) 1988 Obtained a bachelor's degree in engineering from Imperial College London, UK1994 Received a PhD from the University of Pennsylvania in the United States。Professor Huang is currently a professor at the bet365 sports betting app University of Singapore (bet365 sports betting app University of Singapore，NUS) Chair bet365 sports betting app of Guanyintang Buddha Temple, School of Computer Science, also used to be NUS Yang Luling Medical College(Yong Loo Lin School of Medicine at NUS)bet365 sports betting app of Pathology.
Mainly engaged in research on knowledge discovery algorithms and their applications in biology and medicine。In the early stages of your career，bet365 sports betting app Huang has conducted important research work in database query language theory and finite model theory，And has made outstanding development innovations in big data integration systems。bet365 sports betting app Huang published about 300 bet365 sports betting app papers，Contains one of the most cited papers in related fields。
2013 Year，bet365 sports betting app Huang was awarded for his outstanding contributions in database theory and bioinformatics ACM Fellow，Become a benchmark and leader in the field of computer and information bet365 sports betting app around the world。2014 Year, he was also awardedICDT 2014 Time-tested annual award for work on naturally embedded query languages。Same year，Awarded the Public Administration Medal by the bet365 sports betting app Government，In recognition of its outstanding efficiency、Ability and Diligence。
Reporter: Professor Li Jinyan, Shenzhen University of bet365 sports betting app
Report title:“Water squeeze watertight”Double hydrophobic theory and reverse expansion
Date and time：2024Year5month8日(Wednesday), PM16:00 – 17:00
Reporting location:Computer Building 313
Report Summary:I am here to talk about a hot issue in structural biology:How to identify a subset of amino acids with high binding energy in protein complexes。We have two solutions。One is proposed“Water squeeze watertight”Double hydrophobic biological theory and using the maximum bimolecular graph data mining algorithm to find the subset of amino acids with high binding energy and the amino acids surrounding themO-ring。Because this crude solution cannot provide which amino acid mutations can greatly enhance the affinity of the protein complex，We propose an artificial intelligence deep learning method that combines adversarial and generative methods to predict the positions of amino acids that need to be mutated and recommend what new amino acids these amino acids should be changed into。These theories and algorithms are very useful for protein drugs andmRNAVaccine design optimization will bring many benefits。These results have been published in "Bioinformatics》(2007、2009、2010) and《Nature Machine Intelligence》(2024).
About the speaker：
Li Jinyan，Doctoral Supervisor、Distinguished Professor of School of Computer Science and Control Engineering, Shenzhen University of bet365 sports betting app、Researcher at Shenzhen Institute of Advanced bet365 sports betting app, Chinese Academy of Sciences、2022bet365 sports betting app High-level Overseas Key Talents of the Year, selected among the top in the world2%List of top scientists。Worked full-time at UTS、Nanyang Technological University、Information and Communications Research Institute and other well-known universities and scientific research institutions in Australia and bet365 sports betting app have been engaged in teaching and scientific research recently30Year。Long-term commitment to bet365 sports betting app and innovation related to cutting-edge topics in data mining and bioinformatics。Proposed“Reveal Mode”Theory and mining algorithm, water squeeze and water tightness“double hydrophobic”Biological hypothesis、One-to-one mapping relationship between maximum bimolecular graph and closed mode。Published in top journals and international conferences in the field of machine learning and bioinformatics200Multiple high-quality academic papers，Among them, the number of original papers cited in a single article1500remaining times。Presiding over multiple bet365 sports betting app research funds of Australia and Singapore。Won the prize“Asian bet365 sports betting app Innovation Gold Award”、“Data Science Innovation Award”etc. Recent cross-reference of biological sequence big data“Chain”Compressed、Protein affinity mutation prediction and high-throughput sequencing errors based on adversarial learning“String ladder”Proposed high-performance algorithm for error correction。Efficient and accurate assembly of viral pan-metagenomic sequences、Special focus on the design and optimization of multi-component messenger ribonucleic acid vaccines and multi-component inactivated vaccines。Awarded a Bachelor’s Degree in Applied Mathematics from the bet365 sports betting app University of Defense Technology、Master's degree in computer engineering from Hebei University of Technology、Ph.D. in Computer Science and Software Engineering from the University of Melbourne, etc.。
