Report title: bet365 live casino and sports betting intelligence technology for discovering new targets for synthetic lethal anticancer drugs
Time：Thursday, November 7, 2024 4:00 pm
Location：Computer Building313
Content introduction:
Discovery of cancer drug targets for cancerPrecision targeted therapy plays a key role. Synthetic lethality（Synthetic Lethality, bet365 live casino and sports betting) is a genetic interaction that usually occurs between two genes，its definitionIt is perturbation of these two genes that kills the cells, butonlyPerturbation of one of the genes does notInfluence the survival of cells。SL is a cancer drug targetGold Mine, becauseTargetWith cancer-specific abnormal genesbet365 live casino and sports betting Partnergene,Can selectively kill cancer cells without harming normal cells。Current wet screening methods are often costly，While statistical and machine learning methods cannot make full use of prior knowledge or lack itYesExplanationSex. We have developed a seriesBased onKnowledge Graph (knowledge graph, KG）, graph neural network andExplainable bet365 live casino and sports betting Intelligence (explainable AI, XAI)’s deep learning method to predict bet365 live casino and sports betting and understand behind itBiological mechanism。SynLethDB isDeveloped by usoneCollected manyComprehensive database of bet365 live casino and sports betting gene pairs, includingA nameSynLethKG’s knowledge graph。KG4SL is the first method to use KG for bet365 live casino and sports betting prediction (ISMB/ECCB 2021)。PiLSL further focuses on learning pairwise interactions from KGs to predict bet365 live casino and sports betting，and interpretable (ECCB 2022)。After, we proposedKR4SL，It employs path-based knowledge reasoning to rank bet365 live casino and sports betting candidate partners for a given major gene，ableCompareClear explanationbet365 live casino and sports betting prediction and biological mechanisms (ISMB/ECCB 2023)。Latest，We analyze the graph neural network-based methods published in recent yearsSLThe prediction method has been systematically benchmarked，Summary discusses the progress and pain points in this field (Nature Communications 2024). at present,We are combining pre-trainingLargeLanguage model (egBERT，GPT) andKnowledge Graph，To addbet365 live casino and sports bettingPredictive generalization and generation of natural language explanations。
Speaker profile:
Dr. Zheng Jie is currently working as a researcher at the School of Information Science and Technology, ShanghaiTech University、Chanpin(tenured)Associate Professor、Ph.D. Supervisor，And serves as co-director of the Intelligent Medical Information bet365 live casino and sports betting Center。He received his bachelor’s degree and Ph.D. degree in computer science from Zhejiang University and University of California, Riverside respectively，And at the National Institutes of Health (NIH) National Center for Biotechnology Information (NCBI) engaged in postdoctoral bet365 live casino and sports betting。Before returning to China，He served as an assistant professor at the School of Computer Science and Engineering, Nanyang Technological University, Singapore，And serves as the Singapore Agency for Science, Technology and bet365 live casino and sports betting (A*STAR) Genome bet365 live casino and sports betting Institute (Genome Institute of Singapore) Guest researcher。In the past three years, his bet365 live casino and sports betting results have been published as the corresponding author (or co-corresponding author) inNature Communications、Bioinformatics、IEEE JBHIand other journals, andISMB/ECCB、AAAIWaiting for top conferences and serving asISMBandRECOMBProgram committee member of the Computational Biology Flagship Conference.2019Dr. Zheng was selected as the winner of Shanghai Municipal GovernmentDistinguished Professor of “Oriental Scholars”。Dr. Zheng has long been committed to the research of bioinformatics、Computational Biology、Research on the intersection of bet365 live casino and sports betting intelligence and biomedicine。Currently，His research focuses onAIPharmaceutical、Protein bet365 live casino and sports betting Intelligence and Data Science、Cancer precision medicine and other directions。
